A Brief History of Grow Lighting — Part Two

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We continue into the second part of an entertaining set of articles from ILUMINAR, focused on the “brief” history of artificial grow lighting.

Click here to read part 1!

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


Disclaimer

This article was originally published on the Iluminar blog. If you would like to read the original article, please click here.

It might have occurred to you that this brief history of grow lighting isn’t actually all that brief, as we’re now into our second post and haven’t even got to High Pressure Sodium (HPS) lamps yet. It even shocked us when we started doing the research, but believe it when we say that this is, in fact, an extremely brief history. We’re skirting around a lot of references and it could be argued that we abridged too far (pun intended); in reality we bit off more than we could chew. There are an awful lot of clever ideas that went into modern lighting technology and it’s nearly impossible to cram it all into a single blog.

Still, there’s no harm in trying – so here we go again.


Whitesnake knows what we’re doing. Here we go again.

In part one we left you somewhere between Geissler tubes in 1857 and the birth of the fluorescent light in the 1920’s. At this point, it would be wise to avoid confusing you further with our trip down gas “glow” discharge technology and side-step into the world of the gas vapor discharge lighting. The reason we are ditching fluorescent lighting is that in reality its low intensity limits it to close-proximity crops that are a tiny fraction of the the horticultural lighting industry. Perhaps we’ll look at them in detail in a later post, but there are bigger historical fish for us to fry.

Enter the low pressure mercury vapor lamp. Although mercury lamps using electrical arcs can trace their lineage back to 1835 for the first observed mercury arc itself, and 1860 for the first mercury vapor light, the first commercial success was in 1901 at the hands of Peter Cooper Hewitt, whose low pressure mercury vapor lamps were used in many industrial applications including street lighting. However, this design was very crude and required a lot of mercury. By the 1930’s, improvements from OSRAM-GEC and General Electric had turned the mercury vapor lamp into a far more viable luminaire for general use.

At the same time that mercury vapor lamps were being improved, a gentleman named Arthur H. Compton, a future Nobel winner, invented the first low-pressure sodium (LPS) bulb. It didn’t work very well, because the alkali metal sodium kept destroying the electrodes and eroding the glass, but it showed serious possibilities. Sodium lamps are desirable due to their extremely high efficiency when converting electrical energy into usable light. The only catch is that high efficiency results in light which is almost entirely yellow and is therefore limited in its application.

Regardless, in 1932 a tiny Dutch company called Phillips launched the first commercially viable LPS lamp. Just four years later, in 1936, the same tiny Dutch company launched the first commercial high-pressure mercury vapor lamp. The new high-pressure lamp was based upon breakthrough research from German researchers Kuch and Retschinsky, who in 1906 developed the fused quartz arc tube. Using quartz instead of typical glass allows mercury to vaporize at much higher pressures, thereby boosting efficiency. Are you starting to see where the high-pressure sodium (HPS) comes from yet?

Haha, fooled you, because that’s not how we actually got to HPS lamps.

Why? For the same reason that Arthur H. Compton’s original LPS lamp failed: Sodium is a very aggressive metal alkali, and when it’s vaporized, it simply eats its way through most glass, silica or quartz-based materials. You can’t sustain a sodium lamp reaction in a fused quartz arc tube because it just doesn’t work for long enough to be viable.

The next stage in our story is prompted not by the invention of a lamp, but by the invention of a new material with a rather funky name: Lucalox. Lucalox was the invention of Robert L. Coble of General Electric and was the GE brand name for a material that we know today as aluminum oxide ceramic, an extremely heat-resistant and strong material that can withstand the highly caustic nature of sodium vapor at the pressures necessary to improve both the color rendering index (CRI) and the lifespan of the bulb.

However, it would still be another nine years until yet another GE team would present the world with it’s first high pressure sodium bulbs in 1964. This team was made of William Louden, Kurt Schmidt and Elmer Homonnay. With further developments and improvements made in the 1980’s, HPS rapidly became the most common street lamp in the world, and the workhorse of supplemental lighting in greenhouses around the world. But there was still much more improvement to come.

Throughout the history of the lighting industry, supplemental agricultural lighting has always borrowed technology that was been developed for people and not plants. Thus the adage, “Lumens are for Humans.” Well in this case it’s literally true.

However as world populations continued to grow over the 20th century, a new need for artificial lighting began to take shape: lighting specifically designed for plants. In the latter half of the century things began to change…

Thanks for reading!
The ILUMINAR team


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  1. Website: https://www.iluminarlighting.com/
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About the Author

Iluminar is a veteran lighting brand with growers behind the wheel. We have spent our years under lights as well. We have been in the industry for over 20 years and proud of it.


How the Police Benefit from Cannabis Legalization

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Hunter Wilson of Growers Network details how cannabis legalization has not only helped the cannabis industry and its consumers, but also the police. Ending cannabis prohibition has opened up police resources to focus on crimes that actually harm people.

The following is an article produced by one of our authors. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.

One of the biggest arguments coming from proponents of cannabis prohibition is that cannabis is directly associated with violent crime1 and other illegal activities. You can clearly see this in how Attorney General Jeff Sessions talks about "marijuana":

I believe it would be unwise for Congress to restrict the discretion of the Department to fund particular prosecutions, particularly in the midst of an historic drug epidemic and potentially long-term uptick in violent crime. Jefferson Beauregard Sessions III

Jeff Sessions clearly believes that cannabis is associated with violent crime. But does the logic that hold up when scrutinized? Let’s take a look at some relatively recent studies examining the relationship between legalized cannabis and crime levels, and arrive at our own conclusions.


Border Security


The first study we shall look at is entitled “Is Legal Pot Crippling Mexican Drug Trafficking Organisations? The Effect of Medical Marijuana Laws on US Crime”, published on the 9th of June, 20172. In the journal, the authors explain that drug trafficking organizations (abbreviated as DTOs) are associated with violent crimes and other crimes near border regions, particularly in the American Southwest. In large part, many US border protection policies have been targeted at reducing the strength and effects that these DTOs have. Until recently, DTOs were one of the primary sources for cannabis in the United States, and had a firm control on the black market for cannabis.

WHO'S A GOOD BOY?

It logically follows that if the US is producing its own cannabis now, and not relying upon DTOs for it, the price of cannabis should drop substantially. Profit margins for DTOs importing cannabis into the US should vanish. If the profit for cannabis is gone, naturally DTO activities should decline as well.

So what did the authors of the paper find? By examining Uniform Crime Reports (UCR) data and Supplementary Homicide Reports (SHR) data and controlling for plausible variations in DTO activity, they found that the implementation of Medical Marijuana Laws (Or MMLs) in states bordering Mexico were associated with “a strong reduction of 12.5% in the violent crime rate for counties close to the Mexican border. Moreover, within Mexican-border states we found that the strongest decrease in the violent crime rate occurs in counties in close proximity to the border while the effect weakens with the distance of a county from the border.”

The authors of the study also noticed a spillover effect as well. States that neighbored those with MMLs also saw a decrease in the violent crime rate near their borders.


Crime Clearance Rates


One metric of police effectiveness is denoted as “Crime Clearance Rates.” Essentially, the crime clearance rate is the ratio of crime cases that have been resolved to crimes cases that have been reported3. The higher the ratio, the better a law enforcement department or agency is at solving cases and prosecuting criminals. How the ratio is determined varies from agency to agency, so comparing agencies’ internal metrics is often the most valid method of determining improvements or declines.

In a study published on July 4th, 2018, authors found that legalization of cannabis resulted in no statistically significant decrease in crime clearance rates in states that legalized cannabis based on statistics in the UCR. Instead, they found that some crime clearance rates actually increased at a statistically significant rate4. Specifically, they found that:

  1. Arrest rates for cannabis possession declined. After legalization in 2012, possession arrests dropped nearly 50% in Colorado and more than 50% in Washington. (Editor’s Note: I feel like this was probably an obvious result of legalization)
  2. Violent crime clearance rates ticked up.
  3. Burglary and motor vehicle theft clearance rates "increased dramatically."
  4. Property crime clearance rates increased dramatically and reversed a gradual downwards trend in Colorado. 5

While the decline in arrests for possession should be an obvious result of legalization, the latter three clearance rate increases are particularly striking. Violent crime, burglary, motor vehicle theft, and property crime clearances rates all saw statistically significant increases. Colorado and Washington were states that, prior to legalization, were seeing downwards trends in their clearance rates for these crimes. With the sudden and full reversal on prohibition, there was also a sudden increase on clearance rates. While correlation does not imply causation, it should seem apparent that legalization has opened up police resources to pursue other crimes.


Knock-On Effects


One of the more interesting consequences of cannabis legalization though, is its effect on other crimes. According to a study by the University of Bologna in Italy (Editor’s Note: I know, I know, the University of Bologna. I had a good laugh too), several other measurements of criminal activity dropped dramatically after Washington legalized cannabis, and those same measurements also dropped in Oregon when it legalized cannabis two years later6.

Among some of the crimes you would expect to decline (such as criminal possession), other crimes and negative behaviors also decreased, including:

  1. Number of rapes went down. (by 15-30%)
  2. Property crimes dropped. (by 10-20%)
  3. Normal drinking and binge drinking diminished.
  4. Other drug usage also declined. 7

The only notable crime that increased was driving under the influence of cannabis, which is unsurprising as a direct consequence.


In Conclusion


Legalization is a positive outcome for the cannabis industry and its consumers. There is a direct benefit to legalization. But more importantly, there is a benefit to our society as a whole and law enforcement agencies can dedicate more resources to crimes that have victims.

Many critics of legalized cannabis have claimed that legalization will lead to an increase in crime, yet studies have shown the exact opposite. Why? I’ll leave you with some excellent hypotheses posited by the authors of the study from the University of Bologna:

  1. “First, cannabis use determines a variety of psychoactive effects, the most commonly reported one being a state of relaxation and euphoria. Thus, increased consumption of marijuana reduces the likelihood of engaging in violent activities.”
  2. “Second, this effect is reinforced if cannabis is a substitute for violence-inducing substances such as alcohol, cocaine and amphetamines. Studies generally find that marijuana and alcohol are substitutes. Our own results show that the legalization of recreational marijuana increased its consumption while reducing the consumption of other substances, including alcohol. These two channels may explain, in particular, the estimated drop in rapes. Consistent with this possibility, recent research shows that men consuming cannabis are less likely to engage in sexual aggression against their partners than men consuming alcohol.”
  3. “Third, the legalization of recreational marijuana may induce a reallocation of police efforts away from cannabis pushers and consumers and towards other types of offenses. Such reallocation of police effort may be reinforced by expectations, and therefore its effects on crime have arguably materialized before the actual opening of dispensaries and legal retail trade in WA following the 2012 vote. This would be consistent with detecting an impact on crime rates as soon as 2013-2014. This channel is consistent with a reduction of crime across the board.”
  4. ”Finally, the policy may have reduced the role for criminal gangs and small criminals in local cannabis markets. The legalization of recreational cannabis leads to the emergence of a legal market, which offers more safety and more reliable product quality via legitimate business. This likely drives illegal sellers out of the market. This mechanism fits recent empirical evidence that illegal markets are causally associated with crime and it may explain both the drop in rapes and thefts that we find. To be clear, we don’t know what previous dealers do after the legalization of the cannabis market, so this argument remains necessarily incomplete.”

Hopefully, the only thing cannabis legalization will leave us worried about are couch potatoes.


References


  1. https://www.washingtonpost.com/news/wonk/wp/2017/06/13/jeff-sessions-personally-asked-congress-to-let-him-prosecute-medical-marijuana-providers/?utm_term=.da488050de74
  2. https://onlinelibrary.wiley.com/doi/full/10.1111/ecoj.12521
  3. Greene, Jack R. The Encyclopedia of Police Science. Routledge, 2007.
  4. http://journals.sagepub.com/doi/10.1177/1098611118786255
  5. https://www.sciencedaily.com/releases/2018/07/180724110031.htm
  6. https://www.sciencedirect.com/science/article/pii/S0167268118300386
  7. https://psmag.com/news/it-is-high-time-we-reduced-crime

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About the Author

Hunter Wilson is a community builder with Growers Network. He graduated from the University of Arizona in 2011 with a Masters in Teaching and in 2007 with a Bachelors in Biology.


Electromagnetic Interference: A Double-Edged Sword

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Theo Tekstra of Gavita explains a problem innate to most electronics, and familiar to most growers who use HID bulbs: Electromagnetic Interference.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


Disclaimer

This article was originally published on Garden Culture Magazine several years ago, although the information is still valid today. If you would like to read the original article, click here.

The introduction of high frequency electronic remote ballasts into the market has created a new problem: electromagnetic interference (EMI). EMI consists of high frequency signals which are either conducted (such as through your power cord back to the grid), or emitted in the form of radio waves (such as a high frequency remote ballast). EMI can disrupt or degrade the functioning of other electronic devices. In some cases, this may even lead to life threatening situations, for example, if medical systems or emergency communication systems are influenced. So what is EMI, and what can we do to avoid it? What are the rules and regulations?


Standards

First, let’s get the dull stuff out of the way: there are two classes which define how much EMI a device may emit:

  1. Class A for industrial use
    1. In industrial environments, the EMI levels are allowed to be a bit higher.
  2. Class B for residential or medical use.
    1. Class B, residential use, is more strict than the industrial standard.

Manufacturers of electrical devices need to ensure that they do not emit more than the applicable standard. EMI, however, is a double-edged sword: manufacturers of electronic devices should also make sure that their electrical devices are protected against the influence of EMI from other apparatuses. This, of course, makes things a bit more complicated. Interference you experience may not necessarily come from a device emitting too much, it could well be that the receiving device is not sufficiently protected against EMI.

There are many devices that emit EMI, because they emit radio frequent radiation such as cell phones and radio transmitters. In certain environments usage of these items is restricted, because they could possibly interfere with sensitive systems. Examples include:

  1. Radio studios and theaters, which could experience interference with audio systems and wireless microphones.
  2. Hospitals and airplanes, due to possible interference with critical electronic systems.


Radiated and Conducted EMI

There are two different types of EMI:

  1. Radiated EMI works like a radio wave, and is emitted by the equipment like a radio transmitter. Radio waves are very high frequency: frequencies from 30 kHz and up (long wave). Medium wave, for example, ranges from approximately 500 kHz to 1.7 MHz. This emission can be picked up by devices that are sensitive to these frequencies, without any electrical connection to the device generating the EMI.
    1. Radiated EMI can, for example, hinder cell phone reception, wireless devices such as intercom systems, monitoring systems and radio amateurs, but it can also induce bad readings on sensitive instruments such as pH and ec meters.
  2. Conducted EMI travels through the power cord of the device back to the grid, and is distributed over your mains cables. All devices that are plugged into the same mains supply will receive this automatically. The interference does not stop at your house though: a complete block of houses connected to the same supply can be influenced. The frequencies are approximately 9 kHz to 30 MHz.
    1. Conducted EMI can influence anything that is connected to the same mains supply, and can cause routers to disconnect, computers to fail, loss in data, interference on audio and cable TV systems, etc.

Of the two, the conducted EMI may well be a worse problem than the emitted EMI.


Electronic ballasts and EMI

Electronic ballasts have become popular because they are efficient, lightweight, run relatively cool, provide a stable output regardless of mains voltage fluctuations, and can be controlled. Traditional (low frequency) core-coil ballasts are quite heavy and become very warm. They can be noisy, and some components degrade over time. But the traditional ballasts are cheap, reliable, and cause no interference whatsoever, because they work on the mains frequency: 50/60 Hz!

So why don’t manufacturers make a low frequency electronic ballasts? They do. There are low frequency electronic ballasts as well. Because of the electronic nature of the ballast, they can still cause EMI, and because they are low frequency, they are often big and more expensive. Square wave, low frequency ballasts in particular can be noisy on lamps, resulting in literally vibrating arc tubes. They are also more expensive to produce.

Then there is a huge variety in operating frequency: traditional high frequency ballasts work around 35 kHz, but modern horticultural double ended systems, for example, work at 120 kHz! It’s not only this base frequency that can cause problems. High frequency equipment also generates what we call harmonics, frequencies which are much higher than the base frequency. They easily reach the radio frequent spectrum your other devices are sensitive to. Harmonics are mostly responsible for emitted EMI problems. Sine wave and square wave ballasts both have higher harmonic frequencies. High frequency square wave ballasts in particular generate lots of harmonics and EMI.

Low versus high frequency

Magnetic ballasts output the same frequency as the receive from mains, so 50 Hz in Europe, 60 Hz in the USA. This causes a “flicker” in the light, which actually switches on and off 100/120 times per second. On digital photographs or video cameras you see this as light and dark banding. High frequency electronic ballasts switch so fast that the arc in the arc tube does not extinguish, leading to a higher output and better efficiency.


How to avoid EMI

It is almost impossible to avoid EMI with a high frequency remote ballast. The lamp cord connecting the (shielded) ballast to the reflector is the biggest problem for radiated EMI: it functionally acts as an antenna. The longer the cord, the bigger the antenna. Shielding the lamp cord is not a solution in many cases, as it dampens the ignition pulse and can lead to lamps not starting any more. It also causes losses in output signal, and, in some cases, it actually causes the frequency of the ballast to go up to a much higher frequency, possibly destroying the ballast. This is why in horticulture only complete fixtures are used, with ballast and reflector integrated. The lamp cables are integrated into the metal design, reducing the interference to a minimum.

Conducted EMI is caused by insufficient filtering inside the ballast, or just plain bad design, causing high frequency signals to be delivered back to the grid. This can happen in remote ballasts, as well as complete fixtures.

There are several ways to keep your EMI to a minimum:

  1. Best option: Use complete fixtures! Ballast and reflector are integrated, so there is no loose lamp cord to emit lots of EMI. They are much easier to wire than remote systems, you just need to bring power to your climate room.
  2. Make sure you have a good earth connection. The use of a protective earth connection is crucial to avoid EMI in shielded systems. Always use protective earth for safety, but use it specifically for high frequency devices to provide good shielding.
  3. Keep lamp cords as short as possible, so keep the ballasts as close to the reflector as possible. I am talking about just 15 cm of cable instead of 5 meters or more!
  4. Keep lamp cords separate from mains cords. If you they cross or run parallel you can get induction of the high frequency output on your mains supply, causing conducted EMI. This feedback signal can even destroy your ballast.
  5. Never coil your lamp cords, shorten them! A coil can influence the frequency of your ballast, and can amplify radiated EMI.


Harmonics are mostly responsible for emitted EMI problems

EMI measuring rooms ideally do not contain metal objects close to the sources, all tables on which the objects are placed are made of wood.

Keep your family and neighbors happy and safe

EMI can cause all kinds of mayhem in a domestic environment: Internet routers that lose connection, Wi-Fi access points that decrease in performance or lose connection, TV’s and satellite receivers that show interference, remote controls (for example, to open your garage door or arm your alarm system) that do not work anymore, intercom systems that become unusable because of a loud hum, false alarms in wireless systems, amateur radio traffic interference, etc. When the neighbors call the cable guy to search the cause of the problem you are already too late. It is always better to prevent these problems.


So, what should I buy?

If a device carries an FCC or CE sign it should be compliant to the EMI regulations. I say should be, as in reality there are a lot of things wrong with the testing of electronic equipment. For CE certification, for example, the manufacturer may choose to test the equipment himself, and declare that it is compliant to CE. If it turns out that it isn’t compliant he will probably get a slap on the wrist, which in many cases is cheaper than actually being compliant. Manufacturers in cheap labor countries outside the European Community (where the CE certification is required) do not really care much about compliance, and the importer or distributor is held responsible.

For FCC compliance, the device needs to be tested in a lab which is accredited by the FCC. In reality though, there is a huge difference in reports that are obtained from different (accredited) labs from different countries, also depending on how they test. If you test a ballast, for example, with just 15 cm of lamp cord it will give you a much better result than with 4 meters coiled next to the ballast. An FCC approval is no guarantee for absence of EMI.

Be smart when you design a climate room. Think ahead, and choose products from a reliable manufacturer. Realize that all high frequency remote ballasts (even those that are FCC approved) can emit EMI and that in all cases it is better to use complete fixtures. If you use remote ballasts, then place the ballasts as close to the reflectors as possible, and use very short leads. Never cross lamp cords and power cables, and make sure all your systems have perfect ground connections.


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Resources:

Want to get in touch with Gavita? They can be reached via the following methods:

  1. Website: https://gavita.com/
  2. Email: info@gavita.com

Do you have any questions or comments?

Feel free to post below!


About the Author

Theo Tekstra is a horticultural lighting expert, mostly known for his work at Gavita. He is a contributor to many publications, such as Ed Rosenthal's Marijuana Grower's Handbook and Jorge Cervantes' Grow Bible, writes articles and columns for magazines, is a speaker at international events and visiting professor at Dutch horticultural schools. His insights and experience from a breeding, growing as well as a horticultural lighting point of view give him a unique perspective into cannabis cultivation. For many years he led the largest Dutch online cultivation community and he has thousands of posts on international fora and in special interest groups.


OregonCBD Uses Intelligent Breeding and DNA-Based Tools to Disrupt the Hemp Extract Market

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Liam Kane of Medicinal Genomics explores how a new CBD producer has used genetic equipment to amp up their production quality and speed.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


Disclaimer

This Contributors article has been reproduced with permission from Medicinal Genomics. The original article can be found here.


Intelligent Breeding and DNA-Based Tools


In a recent episode of the Shaping Fire podcast, host Shango Los spoke with Seth Crawford, Ph.D. to discuss his blooming seed business, Oregon CBD. The published sociologist entered the industrial hemp market in 2015, partnering with his brother Eric.

Their goal was to disrupt the hemp extract market by breeding CBD-rich plants derived from medical cannabis plants, instead of starting with the low-cannabinoid, low-terpene hemp plants that were being used to make extracts. By using intelligent breeding techniques and innovative tools, such as the youPCR™ Plant Screening Platform, Crawford and OregonCBD were able to do just that.

In the the interview, Crawford highlights the lack of scientific support for CBD isolate and the abundant evidence that points to the strength of the entourage effect. The diverse array of cannabinoids and terpenes in cannabis creates a unique pharmacology that is far more effective than isolated compounds. Because they wanted to create a CBD-rich cultivar with a robust terpene profile, the Crawford brothers took a different approach to seed production. Rather than attempting to breed the CBDAS allele (CBDA Synthase, a protein that produces CBDA) into hemp plants, as was typical for the CBD isolate business, they instead bred out the THCAS allele (THCA Synthase, a protein that produces THCA) from medicinal cannabis lines. They did this by inbreeding multiple Type II plants (1:1 CBD:THC ratio) to get multiple genotypes:

  1. 25% Type I progeny (THC dominant)
  2. 50% Type II progeny
  3. 25% Type III progeny (CBD dominant with <0.3% THC)

Editor’s Note: The above is a typical Punnett Square set of probabilities for two parents that are heterozygous for a single gene. It is likely that there are multiple genes encoding these proteins.

Using the youPCR™ Plant Screening Platform, Crawford was able to identify plant genotypes of seedlings that were only days old. This enabled the OregonCBD team to get early feedback on their efforts and accelerate their breeding project.

In addition to these newly developed, rich chemotype plants, Oregon CBD made significant advances in the plants’ growth abilities. The breeders also introduced genes from high CBD, high-terpene autoflower and early flower lines. These innovations allow farmers to maximize the efficiency of their production space and grow time. Autoflower plants require no shift in the light cycle in order to begin flowering, instead beginning to flower once a critical size is reached. Early flower lines are “photoperiod sensitive”, allowing hyper-tailored harvest times.

Editor’s Note: Autoflower genes originate from Cannabis ruderalis, a relatively wild type of cannabis.

In the interview, Dr. Crawford went on to discuss various stories and quirks he encountered throughout his experiences. One thing he has observed is when female plants adopt a male phenotype (sometimes referred to as “herming”). He explained that, by employing Medicinal Genomics’ youPCR Gender Detection test, he confirmed that these plants lacked a Y chromosome, were therefore female; however, they exhibited male characteristics and produced pollen. Observed in approximately 1 in 4000 plants, the scientific dynamics of the phenomenon remain unclear.

Finally, Dr. Crawford discussed OregonCBD’s newest cultivar group, CBG-rich plants (Type IV). CBG (Cannabigerol) has been shown in preliminary research to have potent analgesic effects, without the psychoactivity of THC. The development of Type IV cultivars will allow for a far more specialized cannabinoid market, opening the door to immense breeding potentials to create highly varied chemoprofiles. Breeders who want to breed their own CBG-rich plants can identify them in the seedling stage by running screening tests that look for THCA and CBDA alleles. If neither is present, it’s a Type IV plant.

If you would like to listen to the full podcast, click here. If you’d like to see podcasts from Growers Network, let us know, and check out our first three episodes here.


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Want to get in touch with Medicinal Genomics? They can be reached via the following methods:

  1. Website: https://www.medicinalgenomics.com/
  2. Phone: 866-574-3582
  3. Email: info@medicinalgenomics.com

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About the Author

Liam Kane is a Research and Development Intern at Medicinal Genomics Corporation, and is currently enrolled at Northeastern University studying Neuroscience and Bioinformatics. In addition to cannabis genomics and pharmacology, Liam enjoys playing guitar, snowboarding, and listening to music.


U.S. Markets See First Cannabis IPO

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James Rieger of Tannenbaum Helpern Syracuse & Hirschtritt LLP discusses recent financial developments in the Nasdaq stock market and what it portends for the future of cannabis financial investment.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


July 19th, 2018 saw rapidly growing Canadian marijuana cultivator and processor Tilray Inc. (Nasdaq symbol TLRY) make its debut for trading on the Nasdaq Global Select Market. The IPO (initial public offering) raised $153 million for Tilray and is extremely significant for the burgeoning industry because it marks the first “touching the plant” IPO in the U.S. Prior to now, “touching the plant” companies in either the U.S. or Canada that wished to go public were concentrated on The Toronto Stock Exchange or the extremely popular TSX Venture Exchange. U.S. securities exchange listing requirements continue to prohibit the listing of a U.S.-based medical marijuana company or state legal adult use marijuana company because the U.S. exchanges require that the businesses which list for trading to be conducted in full compliance with the laws of their home country.

Tilray utilized well known U.S. investment bank Cowen and Company as one of its lead underwriters along with Roth Capital Partners and Northland Securities. The shares were priced at $17 per share, above the $14-16 filing range, reflecting strong demand for investors in U.S. capital markets. Remarkably Tilray finished its second trading day at nearly $30 per share, reflecting a robust gain of 75% from the IPO price and giving Tilray a market cap of $2.75 billion for the heretofore money-losing business. Tilray’s IPO filings reported revenues of $7.8 million and an adjusted loss of $5.0 million for its most recently completed fiscal quarter. At an annual run-rate of approximately $30 million in sales, Tilray sells for a robust 100 times sales, which harkens back to some of the highest of high-tech company valuations. In addition to Canada, Tilray has a cultivation business in Portugal and an unusually international business, with operations or agreements to sell in a dozen countries. Tilray checked several other boxes for investors, but having its revenues diversified among both flower, edibles, and other consumables was a major bonus.

Prior to the IPO, Tilray was owned by Privateer Holdings, a cannabis-focused investment fund which is headquartered in Seattle. Tilray is retaining its entire stake but will have super-priority voting rights, which is typically frowned upon by investors. Despite this, investors in the Tilray IPO were willing to look past the voting structure due to the scarcity of U.S.-listed cannabis businesses with perceived strong growth prospects.

Suffice it to say, with the wonderful reception that Tilray received from U.S. investors on Nasdaq, this will not be last cannabis related IPO that occurs in American securities markets. The fact that it occurred at all and was such an amazing success marks a major milestone for the ongoing mainstreaming of the cannabis industry and further erodes remaining bias due to the thicket of legal and regulatory risks that have kept some major U.S. financial institutions and players on the sidelines. The imprimatur of Nasdaq (and what were probably some very interesting discussions amongst individuals at the highest levels of Nasdaq) in approving the listing cannot be overstated. Demand in the U.S. for sizeable cannabis businesses with credible management and well thought-out business models appears to be incredibly strong which should cheer all industry participants and portend massive future capital flows to support the industry’s build-out, capital expenditures and growth.


Footnotes

  1. Canopy Growth and Cronos Group, two larger Canadian marijuana businesses preceded Tilray in trading on U.S. markets but they were simply additional listings of securities already trading on Canadian exchanges and did not involve an IPO.
  2. Canada nationally is set for full adult use on October 17, 2018.

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  1. Website: http://www.thsh.com/
  2. Email: rieger@thsh.com

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About the Author

James Rieger is a corporate law partner at Tannenbaum Helpern Syracuse & Hirschtritt LLP with over 25 years’ experience in the practice of corporate law. James has guided his client in their successful acquisition of a controlling interest in a publicly-traded Canadian cannabis company. James represents public and private companies, hedge funds, merchant banks, private equity funds, exchange traded funds, venture capital funds, investment banks, underwriters, and private investors in many types of transactions, including public and private debt and equity offerings, credit facilities, mergers, acquisitions, fund formation, activist investments, restructurings and divestitures of assets and divisions. James counsels companies and funds on their filings under the Securities Exchange Act of 1934 and their participation in tender offers, proxy contests, and other hostile takeover actions. James also handles general corporate matters, including employment agreements, contracts, cannabis related matters, and joint venture agreements.


The Economy of Efficiency

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Jonathan Valdman of Forever Flowering Greenhouses explains how cannabis manufacturing needs to shift away from prohibition-style grows that were inefficient but profitable to more efficient grows that maintain that profitability.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


Disclaimer

This article was originally published on Forever Flowering Greenhouses website. If you want to read the original article, click here.

The economy of efficiency. It seems obvious to me now after Scott Zeramby of Mendocino Agriculture mentioned it to me. The easiest way to maximize profits is by lowering overhead. The easiest way to lower overhead is to make your equipment and systems as efficient as possible. Historically, this process has been skipped by many in the industry due to the large profit margins that cannabis used to bring in. Back then, the only real reason for people to become extremely efficient was because they were concerned about their impact on the environment, their surroundings, and their carbon footprint. In today’s market, efficiency is extremely important in determining a company’s bottom line, and in most cases these days can mean the difference between a profit and bankruptcy.

I was prompted to write this after seeing headlines the other day explaining how shops in Washington were facing an excess of inventory and people were dropping their prices to move their products, in turn causing a big scare due to the high costs of production, taxes, and a small profit margin for producers. Regardless of all the variables that go into it, including current regulatory policies, implemented taxes and more, I saw a simple solution: Lower your overhead!

Environmentalists love this idea because it also reduces the carbon footprint and investors like this idea because it means higher profits and the ability to expand. One of the most obvious means to become more efficient in this industry is to grow under the sun. Sun-grown plants are more vigorous than plants grown under lights and they show more resilience to disease. There is no other agricultural business in the world that exists in a fully-indoor grown environment. Now that laws are in place and public sentiment has relaxed there is no reason to hide your plants indoors.

Any farmer with a business plan based solely on an emphasis of indoor growth is coming from an era that did not allow for efficient cultivation (prohibition). Within a greenhouse it is possible to supplement light and heat and grow year-round just like you would inside of a warehouse. There are many styles and brands of lighting these days that focus on efficiency. Though I am not here to suggest which light is the most effective and efficient I can tell you that there are a lot on the market with this concern in mind.

Forever Flowering’s structures come with built-in light meters to turn your lights on and off when natural lighting is not meeting the required light levels. Other systems are available and being developed to take this approach one step further. Built-in light meters on each individual light inside a greenhouse allows a controller unit to adjust light levels to meet lighting requirements. This means that different lights within the greenhouse may be illuminated with different light levels.

Related Article: Want to see other companies working in the controller space? Check out our article on Greenhouses.

Passive cooling and heating system techniques are widespread today and any good consultant can guide you as to how to reduce your inputs. Many companies are sprouting up in this regard, teaching people how to optimize on-site soils, amend their soils, buy in bulk and get away from high cost liquid fertilizers and bagged designer soil blends. The answers are out there and the ones that have been ‘in the trenches’ over the past several decades are now being looked to as the experts in the field.

Roll Out Bench Style Radiant Heating

If you don’t know these methodologies yourself be sure to hire a qualified consultant and/or knowledgeable company in the beginning of designing your project. Money spent in the beginning on this guidance with the proper equipment investments and time spent carefully designing your system will equate to business longevity, profits and the ability to stay ahead of the curve and expand as others in the industry struggle to keep their heads above water.


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  1. Website: http://lightdep.com
  2. Email: info@lightdep.com
  3. Phone: 888-784-4687

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FFG began as a vision one day on the farm – growing, doing it, coming up with ways to do it better. With a background of two decades in the field came the ideas of how to create products for others to do it as well. Each growing cycle provided a deeper understanding of the plants and their needs. With each season came lessons from our experience on how to create a better growing environment that needed less daily input and reduced the margins of error. We are farmers that came to know and understand our field and create greenhouses to service it.


Drain or Reclaim

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Sara Schoenhals & David Berlin of Hydrologic Systems discuss the future of water regulations and how they will affect cannabis cultivation operations.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.

As regulations on cannabis cultivation facilities continue to manifest, municipalities will further investigate power, water, and nutrient usage in the industry. Many operation managers and municipalities have not yet considered regulations regarding water usage and wastewater discharge in the cannabis industry. Regulations on these important parts of cultivation would impact cannabis producers dramatically, and possibly even putting some out of business due to slimmer profit margins and competition.

Let us not stick our fingers in our ears and pretend this day will not come. As the industry evolves, new water regulations could jeopardize an existing operation’s legal status. Drought-stricken states like California, Nevada, and Arizona will likely develop regulations on cannabis cultivation operations. Water volume usage and discharge will be something municipalities in those states will closely consider, if they haven’t already.

The two main water regulations on cannabis cultivation facilities concern volume usage limitations and wastewater quality regulations. If a facility is regulated based on the quality of its discharged water that runs into the sewer, the runoff water must be processed with a variety of methods. These methods include:

  1. Filtration and recycling
  2. Off-site shipping
  3. On-site evaporation
  4. Evaporation ponds
  5. Dilution, and/or
  6. Processing through artificial wetlands

If a municipality regulates a facility’s daily water volume usage, that facility must pursue one of the following:

  1. Cut back on planned or operational plant production
  2. Install a recirculating hydroponic system
  3. Filter and reclaim runoff water for irrigation, or
  4. Do all three

Water discharge regulations create a financial and legal incentive for cannabis producers to create facilities that feature “Zero Liquid Discharge.” However there are many challenges associated with building these types of systems as you will see.

Moving toward Zero Liquid Discharge means moving away from the traditional agricultural method of “drain-to-waste” systems. The runoff from a drain-to-waste system is almost always sent into the sewer systems, which is a big concern for regulators as such waste places heavy burdens on water treatment facilities and sewer systems. Closed-loop systems are possible, however, input costs can be higher when compared to a traditional drain-to-waste system. A system that can recycle all runoff water on a large scale is generally extremely specialized and the entire facility or operation must be engineered around this concept. Closed-loop systems require constant water testing and generally at some point require some sort of wastewater discharge, which then may also need to be processed further.

Editor’s Note: Curious about closed-loop aquaponic systems? We’re doing a series on them right now! Check out the first article here.

As an alternative, processing run-off water on-site for recycling and volume reduction is used by a large variety of industrial facilities today. Reverse osmosis (RO) filtration systems are the least energy-intensive and most economically sustainable way to remove dissolved solids from runoff water. However, the RO process produces highly concentrated wastewater that must be trucked off-site or evaporated.

Another potential option is a wastewater evaporator, which is extremely energy-intensive and produces a sludge-like waste that must still be trucked off-site.

Integrating RO and distillation/evaporation is generally the most economical way to truly achieve Zero Liquid Discharge; however, such systems are still extremely expensive. These systems are most efficient when they are designed to treat large volumes of water, which makes them the most suitable option for extremely large commercial/industrial operations. Smaller facilities will generally need to take the approach of water conservation via different growing methods that use as little water as possible, and reducing the volume to be shipped offsite for treatment.

While the above methods are all industrial solutions to treat agricultural runoff water, there are a few biological solutions that we haven’t mentioned yet. The main contaminants in runoff water can be analyzed in a laboratory and, in many cases, the runoff can be treated in artificial wetlands. In an artificial wetland, runoff water with dissolved nutrients is placed into the system and a variety of bacteria, plants, and other organisms convert the nitrogen-based fertilizers into actual biomass. This is a great solution for any facility that has proper permits and the requisite land to do this. The problem is that these types of systems do not work in an industrial area where there isn’t much land area available for relatively low prices.


What is the answer for facilities dealing with water volume usage limitations?

Many facilities dealing with daily limits on water volume usage filter their runoff water (including nutrient runoff and condensate water from climate control systems) to reuse for irrigation. These facilities typically use reverse osmosis to purify nutrient runoff water prior to irrigation. Condensate runoff (from climate control systems) does not need to be treated with reverse osmosis, and can be reclaimed using alternative treatment methods.

Editor’s Note: Condensate water can typically be treated with UV light to eliminate bacteria and mold, filtered, or also run through RO systems.


What about drain water discharge regulations?

Facilities dealing with concentrated water discharge regulations typically must truck all nutrient runoff water off-site. Many operations pay for this water to be taken away by the gallon.

However, one trick that minimizes the liquid discharge from a facility is using an RO system to further concentrate the contaminants from wastewater streams so that there is a smaller volume of wastewater that needs to be disposed of with reduced frequency.


Conclusion

While regulations will make life more difficult for cannabis cultivation facilities, we need to understand why these rules are being put into effect. Fresh water is a precious resource and must be conserved, particularly in dry areas. High levels of nutrients that are discharged into the environment can have dramatic negative consequences, which can be seen from industrial agricultural practices. Wastewater treatment plants may have difficulty treating a high volume of nutrient-rich water from hydroponic facilities, and regulations must take this into account to maintain proper infrastructure.

Whether your cannabis cultivation facility is already in operation or just being built, speaking with your municipality about current or impending water regulations will become critical to maintaining a sustainable, legal, and competitive operation. Not preparing for water regulations yet? They are likely to come — especially if you’re in an area where water is a scarce resource. Consider your options wisely.


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  1. Website: https://www.hydrologicsystems.com/
  2. Email: info@hydrologicsystems.com

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HydroLogic Purification Systems® specializes in a wide range of professional quality water purification products designed for use in many applications including gardening and hydroponics, residential, aquarium, or commercial.


Marijuana Licenses in California – Part 4: Retail and Dispensing

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Ed Keating of Cannabiz Media continues his series about cannabis licenses in California. Today we're looking at retailers, dispensaries, and delivery services.

See Part 1 here!
See Part 2 here!
See Part 3 here!

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


Disclaimer

This article was originally published on Cannabiz Media. To see the original article, click here.

The Bureau of Cannabis Control is responsible for licensing retailers/dispensaries, distributors, testing laboratories, microbusinesses, and temporary cannabis events in California. The term “dispensary” isn’t used in California to identify medical cannabis dispensaries like other states might. Instead, California chooses to differentiate between the adult-use and medical markets by granting the title of “adult retailer” and “medicinal retailer” licenses.

Editor’s Note: Want to learn about cannabis microbusinesses? Check out this article on the subject.

Retailer licenses in California are further categorized by the operations the licensed business is involved in:

  1. Non-Storefront Retailer (Delivery): A licensed non-storefront retailer sells and delivers cannabis or cannabis products to consumers. While the retailer must have licensed premises, those premises are not open to the public (as described by the “non-storefront” descriptor). Instead, sales are conducted exclusively via delivery.
  2. Retailer (Storefront Sales): A licensed retailer sells and delivers cannabis and cannabis products to consumers through licensed premises that are open to the public. Retailer sales can also be conducted via delivery.

Excluding micro-licenses, there are 815 retail licenses in California with a slight bias towards medicinal retailer licenses (54%) over adult retailer licenses (46%) as shown in the chart below. Please be aware that this does not mean there are 815 licensed retail outlets; Some license holders have secured both adult and medicinal licenses at the same location.

Editor’s Note: The proportion of medicinal retailers to adult retailers will likely change over time, especially if you consider this information from MJ Biz Daily.

The 815 retailer licenses can also be broken down by type of activity, as shown in the chart below. 44% of all licenses were held by medicinal retailers with storefronts, 37% were held by adult retailers with storefronts, 9% were held by medicinal delivery-only retailers, and 9% were held by adult delivery-only retailers.

Keep in mind, California’s recreational marijuana market is only three months old, so all of these licenses are temporary at this point in time and are subject to change.


Where are California’s Marijuana Retailer Licenses?

Nearly half of all marijuana retailer licenses (49%) are held in just three of California’s 58 counties: Los Angeles County (28%), Alameda County (11%), and San Francisco County (10%). Expanding upon that a bit, more than three out of four retailer licenses (76%) are in eight counties: Los Angeles County, Alameda County, San Francisco County, Sacramento County (9%), Riverside County (6%), Orange County (5%), San Diego County (4%), and Santa Cruz County (3%).

If we look at license concentration by city, 50% of California’s marijuana retailer licenses are in seven cities: Los Angeles (11%), San Francisco (10%), Oakland (9%), Sacramento (9%), Santa Ana (5%), San Diego (3%), and Cathedral City (2%). In total, retailer licenses can be found in 110 California cities.


Who Has the Retailer Licenses in California?

The 815 retailer licenses in California are held by a total of 514 license holders. Like marijuana manufacturing licenses in California, there are no dominant license holders. 232 license holders hold only a single license and 272 license holders have two licenses. As previously mentioned, the majority of license holders with two licenses typically hold complementary licenses (adult retailer + medicinal retailer).

Only three license holders have three licenses (420 Central, Higher Level, and Stone Age Farmacy) while five have four licenses (East Bay Therapeutics, Hometown Heart, KindPeoples, Monex Place Wellness, Inc., and urbn leaf) and two have five licenses (SPARC and The Apothecarium).

It seems likely that there is little concentration in license holders simply because the difficulty involved in complying with regulations in 530+ jurisdictions across the state don’t make strategic sense in California’s current marijuana market.

Looking at the large number of retail license holders that have one license each, it’s possible that many of these license holders are legacy dispensaries that want to keep doing what they’ve been doing for years as the state’s market evolves around them.


Coming up Next in the Marijuana Licenses in California Series

Part 5 of the Marijuana Licenses in California series is coming soon. It will compare California’s marijuana licenses to other states. If you haven’t already subscribed to the Cannabiz Media newsletter, feel free subscribe.


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Ed Keating is a co-founder of Cannabiz Media and oversees data research and government relations efforts. He has spent his whole career working with and advising information companies in the compliance space.


What California is Teaching us About the Impact of Mold

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In this article from Boveda, Rachelle Gordon teaches us how mold in California is teaching us valuable lessons about the importance of proper growing techniques.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


Disclaimer

This article was republished with permission from Boveda. The original article can be found here.

Moldy cannabis isn’t safe to consume or smoke. Firing up moldy cannabis causes mold spores to spread. Trimming off the mold from your cannabis doesn’t fully eliminate the danger either. When in doubt, throw it out.

Mold is one of mankind’s biggest and oldest enemies. There are several different types of mold, many of which can make food unsafe to eat and homes uninhabitable. Depending on the type of mold present and the length of exposure, effects may be mild to severe, and can include coughing, trouble breathing, headaches, vomiting, diarrhea, heart palpitations, and infections in the lungs. People with asthma or compromised immune systems are most likely to be affected by mold, and could potentially lead to death.

Cannabis, just like any other type of produce, has the potential to develop mold. While some cases do appear in the cultivation process, the majority come after harvest, either during the drying and curing phase or in storage, when moisture levels are too high. Although most cultivators know how to prevent mold growth on cannabis, that doesn’t mean that every crop is perfect. Additionally, if an end user doesn’t keep cannabis in a cool, dry place, that stash could also be at risk.


Is legal cannabis completely mold-free?

Marijuana is now legal for medical and/or adult use in 29 states. Each state makes its own rules to regulate cannabis. Testing for mold and other pathogens, therefore, can be inconsistent.

Moisture safety guidelines for cannabis cannot come soon enough. In August 2017, Anresco Laboratories tested several cannabis plants, extracts and edible samples, all from the Bay Area. The results, first reported by San Francisco Magazine, were disturbing, to say the least. Nearly 80% of the cannabis samples tested positive for some type of pathogen; 15% tested positive for mold.

“We weren’t entirely surprised given the unregulated nature of the market for so long,” Anresco spokesman, Kyle Borland said. He added that while it cannot be certain that this round of testing was representative of the California industry as a whole, the results were still concerning.

Mold can also cause substantial financial losses for cannabis cultivators. Should a cannabis sample test positive, the entire batch may have to be destroyed. Because cannabis is still illegal at the federal level, many growers do not have proper insurance to cover these losses. This is why cannabis farmers strive to prevent mold in the first place.

Widely accepted best practices recommend that all cannabis that will be consumed as flow be stored at a 0.55-0.65 water activity level (aW). This can be achieved by storing flower in an airtight container which has a relative humidity (RH) between 55% and 65%. Maintaining this requisite aW throughout the supply chain, from completion of drying through merchandising, ensures safety and quality for the consumer.

Keeping cannabis between a 55% and 65% RH level also optimizes the potency, efficacy, flavor, aroma and taste of the flower. Testing has shown that when cannabis is stored within these proper humidity levels, flower can achieve up to 15% more terpene retention.


How to spot mold on cannabis

There are several ways to detect mold. In addition to professional lab testing, a visual inspection under UV light can be conducted. Signs of mold can include black, grey, white, brown or yellow spots, spores, fuzz or webbing. For consumers who may have kept their medicine in storage long-term, it’s important to do a quick mold check before consuming in case of any developments.

Signs of Moldy Cannabis:

  1. Dampness
  2. Musty, sweet, and stale odor
  3. Grey or white fuzz
  4. Specks of white powder, like white dust


Is this mold on my cannabis?

If you notice tiny white or cream-colored mushrooms on your buds, those are trichomes, not mold. Trichomes are concentrated with THC and other psychoactive cannabinoids. Boveda preserves trichomes by preventing them from drying up and breaking off while inhibiting mold growth. If there is fuzzy white stuff growing on the trichomes, that’s mold. Mold fibers are much smaller than trichomes.


How to prevent mold on cannabis

As mentioned earlier, cannabis can develop mold throughout various points of its life cycle. When the plant is drying and curing, having a well-ventilated space with plenty of fans is essential. Once the plant is dried, it’s important to keep it stored in an airtight container in a cool, dry place. Boveda’s 2-way humidity control is a great way to keep the cannabis fresh while it’s in a container.

Scientists have known for hundreds of years that a saturated salt solution is the only way to effectively add and/or remove moisture and still maintain a specific RH. Without salt, any humidity “control” only has a starting RH that changes wildly as soon as it gives up or absorbs water. A salt-water sachet is the precise and predictable way to store cannabis. Both Boveda 58% and 62% RH levels keep flower well below the moisture level that molds needs to thrive.

Moldy cannabis can be extremely dangerous – especially for medical patients with compromised immunity. Therefore, it’s vital that all medicine be tested and stored properly for protection against any and all pathogens.

By Rachelle Gordon
www.RachelleGordon.net


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  2. Email: dan.cleveland@bovedainc.com

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Boveda invented the world’s first 2-way humidity control in a ready-to-use packet. Inside Boveda’s semipermeable membrane contains all-natural salts and purified water.


Product Formulation: Applying Engineering Principles to Cannabis Products

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Evio Labs tells us why careful planning and process control are essential to ensure consistent high-quality products for your consumers.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.

The Cannabis industry is booming right now. In many markets, competition is stiff and the urgency to create new products is high. In Colorado alone there are 255 Medical Infused Product Manufacturers and 273 Retail Product Manufacturers1 (sometimes called extractors or processors). Across the United States, the number of similar companies is 10 times higher. How do you rise above the competition? How do you differentiate your products? The answer: create a product that sells itself.

The market clearly wants clean and safe products. As regulators enforce an increasing number of public health regulations, the number of pesticide recalls and health concerns will only continue to grow. Companies that wish to survive this period of dynamic expansion and contraction will need to build a client base that both trusts and loves their products.

How is this done? Process Control.


Process Control

Process Control is an engineering discipline concerning the mechanisms, algorithms, procedural steps, and equipment for maintaining the output of a specific process within a desired range2. Any process must be defined, as should all the equipment, equipment settings, documentation, and steps needed to create the product (specifically, Cannabis concentrates).

This process must also be monitored. Monitoring should include testing at various points of product development. Monitoring helps detect an out-of-control situation. Once an out-of-control situation is detected, personnel can bring the process back into control by following predetermined protocols (or SOPs).

Editor’s Note: An “out-of-control” situation does not necessarily mean the process has gone off the rails. It just means it’s outside of the normal, desired situation.

The purpose of process control is to ensure a process is predictable and operates at its highest efficiency within normal variability, which is extremely useful to both employees and managers. It is also used to quickly identify and resolve process problems, in addition to identifying situations where the process could be improved. Thorough process control should increase product throughput and yield, decrease energy consumption, decrease off-specification (or non-compliant) product, increase safety, extend equipment lifetimes, and decrease labor costs. Compliance with process control is a major part of current Good Manufacturing Practices (cGMP), and when Cannabis becomes federally regulated, those companies following cGMP as well as 21 CFR 210 and 21 CFR 211 will have a significant head start over those who are not2.


Using Process Control

Now that we understand what process control is, how do we use it? In this article, we will demonstrate where and how to use process control when producing Cannabis concentrates from trim using carbon dioxide (CO2) extraction techniques.

Our first step is to identify an ideal product. What do we want to sell? What is the best product we can manufacture? The answers to these questions will drive every other decision the business makes and dictate the capital expenses that follow. For example, if we want to make an ideal wax or shatter, the extraction equipment and methods will differ. Once the equipment is purchased, we’ll need to optimize our operation procedures for the equipment.

The second step in product development is to create a documented production plan. Which products will be made? How do we define an “acceptable product?” If we make a CO2 extract and distill it, is a product with 65% THC our goal? Probably not. Do we only want to sell distillates above 80% THC? What are the terpene concentrations? Do we even include terpenes? These decisions will form any ideal process. Then we can design systems to achieve our goals and begin to define the production process.

Next, we’ll need to test any raw materials! Always do this. What comes out of a process will always depend on what goes in, no matter how talented your personnel are. Remember, when creating extracts, we are concentrating everything that is in the sample, not just the cannabinoids. Were there pesticides in the incoming trim? Heavy metals? What is the chemotype (cannabinoid and terpene concentrations)? Each of these compounds is important because we know that the effects of these compounds are synergistic3. Knowing these starting points will enable us to reliably predict what products will exit the extraction process. It will also allow us to reject poor quality starting materials that don’t meet our internal specifications.


What comes out of a process will always depend on what goes in

This thought naturally leads us into establishing acceptability criteria. Every processing step affects our products; therefore, we need to establish acceptability criteria for each step. Though some variation from batch to batch is normal, acceptability criteria can help us measure what is beyond normal variability and investigate what made a batch fail.

Typically, this is accomplished with control charts in the pharmaceutical industry (and many other industries). Plots showing normal batch endpoints (concentrations, temperatures, pressures) are plotted against upper and lower limits of variability. See Figure 1. When a batch exceeds either of these limits, investigations are performed to answer why. Did a power outage affect the temperature gradient? Was a SOP not followed directly? Control charting makes it easy to define when things go wrong as well as correct the error. The best part of using control charts is that regulators will be overwhelmed with your compliance, and you’ll easily pass any audit you’ll ever have. Additionally, if your trim passes all contaminant tests and has cannabinoid and terpene concentrations that meet your specifications, it can be sold and used for extractions by others.

The tobacco industry has been doing this for decades. How do they make millions of cigarettes all appear and taste the same? The answer is process control during the blending of tobacco batches to meet strict acceptability criteria on chemotype and additive concentrations4. Process control means controlling raw materials and every processing step , and never deviating from this process. Data from each step compared to predefined acceptance criteria is critical to achieving process control. If we don’t test, we don’t know.


Tunable Processes

The next step in our ongoing example is the extraction of the trim materials. Carbon dioxide extractions are sometimes thought of as “tunable processes”. This is because it is possible to manipulate the temperature and pressure of the supercritical CO2 to create the desired products. It also means we’ll need high levels of control to ensure that each processor is achieving the same temperature and pressure gradients for the same time points. Only high-quality training and strong Standard Operating Procedures (SOPs) can guarantee process control and high-quality products. Without process control, we’ll waste time and money wondering why the products are changing batch to batch. This tunable nature gives us opportunities for in-process testing, allowing us to test at different temperatures and pressures to obtain data on how to optimize our initial SOPs. Then we can perform these in-process tests to maintain acceptability criteria for normal batch production. These same principles apply to any extraction technique or technology.

The next step in our product development example is distillation. In distillation, components in a complex mixture are separated by heating them to their specific boiling points and then condensing them in a collection vessel. Highly controlled distillation will result in high purity distillates that are free of contaminants. Good SOPs control the temperature and pressure gradients, as well as the time of the runs, to exact seconds and degrees. Temperature and pressure changes will definitely change the end product.

It should be known what happens if the temperature deviates too much during your distillation. That way, when tracking our control charts, we know what happened when we see lower quality products. At PhylaTech, we see many distillation products that should have hypothetically reached over 80% purity, but the process set points (temperature and pressure) were not controlled, leading to side reactions of THC. The distillation mixture can also affect the concentrate’s final viscosity, which is important if making vape cartridges. The viscosity also affects the stability and shelf-life of products.


Final Products

Now that we’ve established a highly controlled process to produce the best products on the market, do we want to think about drug delivery? All kinds of technologies exist for optimizing product solubility and bioavailability. Examples include spray drying, coating beads, using amorphous solids, achieving size reductions via hot melt extrusion (microparticles and nanoparticles), using lipid formulations, and encapsulating in capsugel. These types of advanced higher-order processes are the topic of future articles, but are important to keep in mind for future business goals.

Product quality depends on you. If you do the homework, do the testing, and control the processes, your products will sell themselves. Remember, a good laboratory isn’t there to just pass or fail products, but will support process development and process control efforts with reliable data and in-depth understanding of any processes.


References

  1. https://www.colorado.gov/pacific/enforcement/med-application-and-licensing
  2. https://www.fda.gov
  3. Russo EB. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. British Journal of Pharmacology. 2011;163(7):1344-1364. doi:10.1111/j.1476-5381.2011.01238.x.
  4. https://cannabisdigest.ca/augmented-cannabis-oil/
  5. http://hemphacker.com/why-winterization-stabilizes-hash-oil-extracts/
  6. Carbonyl Compounds Produced by Vaporizing Cannabis Oil Thinning Agents. Troutt, William D. et al.

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About the Author

Stephen Goldman is an analytical chemist with extensive industrial and academic laboratory experience. He came to EVIO from PhytaTechSM and has expertise in GC, HPLC and mass spectrometry, chemical and biochemical engineering as well as project and business management. Prior to joining PhytaTech, Stephen served as an analytical chemist at the CLIA and CAP certified Forensic Laboratories, overseeing toxicology testing. Stephen has published a number of research papers in the fields of biological and analytical chemistry. He is a member of the American Institute of Chemical Engineers, American Association of Pharmaceutical Scientists and the American Chemical Society. Stephen has a Master of Science in Pharmaceutical Chemistry with Honors from the University of Kansas and a Bachelor of Science in Chemical and Biochemical Engineering from the University of Iowa.