Growers Network Staff

April 10, 2018 8 min read
April 10, 2018
8 min read

Powdery Mildew and Fungicides: Part 1

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Growers Network prefers all cannabis to be clean and pesticide-free. However, there may be occasions when fungicidal use is warranted. In case of those events, Mike Steffes of Quest Hydro has provided us with some simple guidelines on how best to avoid Powdery Mildew and use fungicides in the event of an infestation.

Want to read the first article? Click here.

The following is an article produced by a contributing author. Growers Network does not endorse nor evaluate the claims of our contributors, nor do they influence our editorial process. We thank our contributors for their time and effort so we can continue our exclusive Growers Spotlight service.


This article has been reposted with permission from Quest Hydro. The original article can be found here.

Powdery mildew is a common fungal disease of angiosperms (basically, any plant but conifers). The growing fungus looks grayish white and powdery.

A powdery mildew infection.

Powdery mildew is an infection from one of the many fungal species of the family Erysiphaceae (ee-rhy-suh-facie). Powdery mildews generally live externally from their hosts, and not inside of them. In other words, they are ectoparasites, not endoparasites. This means that powdery mildew is not a systemic infection. It does not grow into parts of the plant or propagate internally throughout the plant.

Furthermore, powdery mildews’ parasitic process requires host cells to remain alive. They are what scientists call obligate biotrophic parasites. Biotrophic pathogens usually cause disease on only a relatively small group of host plants. This is because of the different genetics and molecular processes/structures required for wider ranging host-pathogen interactions.

Side Note: There’s a common misconception about the word “systemic”. Systemic fungicides can attack a non-systemic pest. After you spray a plant with the systemic fungicide, it moves throughout the plant. A systemic pest would also move throughout the plant, but PM is not a systemic pest.

Symptoms and Spread

The first symptoms of a powdery mildew infection are dusty gray or white spots on either side of the leaves. If left untreated, the growing fungus will produce spores and rapidly spread to other leaves, stems, and flowers. While powdery mildew doesn’t typically kill the host plant, it can cause early senescence and stunt the plant’s growth and development. Some plants may show local necrosis when badly infected.

The fungus can be transmitted by pests such as aphids, or via touch, tools, clothing, shoes, and even by airflow through previously contaminated spaces. These transmission methods are called “transmission vectors”, or sometimes simply referred to as vectors.

Potential transmission vectors.

Relative humidity plays an essential role in the control or spread of mold. Molds and fungi particularly like dry leaf surfaces and humid environments. For the best inherent protection during growth phase, relative humidity (RH) should be kept between 40% and 55%. Flowering requires drier conditions, with humidity levels between 25-45% RH.

Editor’s Note: Dewpoint is also a very useful tool for measuring the danger posed by fungi. Ideally you want to avoid any liquid water in the environment. Check out this dewpoint calculator to see how the dewpoint affects mold risk.

One very critical thing to monitor is the night time RH level. The night time RH often spikes and can lead to condensation. Wide RH swings are conducive to powdery mildew infection.

Additionally, crowding your plants can produce pockets of stagnant, high humidity air, so called “microclimates,” so give your girls some room. It’s a good idea to keep the lower fan leaves trimmed to prevent these microclimates.

Prevention Means Standard Operating Procedures

Dedicated shoes, shoe covers, or a boot bath, and hand washing (alcohol based hand sanitizers are good) before entering the grow area are your first line of defense. It’s also a good idea to not wear your outdoor clothes into your grow.

Clean and sanitize tools and equipment that come into contact with multiple plants. Immersing tools for a couple minutes in a sanitizing solution prevents cross contamination with healthy plants. A pint of household bleach mixed with a gallon with tap water will work well. Use this sanitizer solution to spray pots, plant trays, water tanks & pipes, and all other hard surfaces of equipment. However, wetting porous surfaces with bleach doesn’t work. Minimize porous surfaces in your grow rooms.

Between grows, thoroughly sanitize all surfaces with a commercial-duty hard surface disinfectant. Always pre-clean before using any disinfectant. Let the cleaners clean and the disinfectants disinfect. Here are a few potential disinfectants:

Sanitize rooms thoroughly between grows.

  1. Bleach is an effective product. It is easily available and inexpensive. It does have downsides though. Bleach has an irritating odor, it can produce noxious chlorine gas, and is inactivated by relatively small amounts organic matter.
  2. Quaternary ammonium compounds (Quats) have been used for many decades as high performance sanitizers. They work by disrupting the cell walls of bacteria. Quats are known to also apply a heavy selection pressure on fungi. A couple of representatives are:
    1. Naccosan, it sanitizes hard surfaces and inhibits the growth of mold and mildew.
    2. Physan-20 is similar to Naccosan but also has a bit of ethanol (should you feel ethanol ever helps).

Monitor and inspect for plant infections on a regular basis, ideally daily. When a new infection is noticed, infected plant parts should be removed when possible. Place them directly into a plastic bag without waving them around. This is your warning alarm to adjust your treatment regimen quickly. More on this in the Treatment section.

Be sure to change your air filters between grows. Bag the filters as you pull them out and remove them from the premises in a closed trash container. Don’t go walking around with a used filter full of … yeuch.

Fungicides and PM

Fungicides are most often grouped by “mode of action” (MOA). They are split into approximately 42 groups that are assigned by the Fungicide Resistance Action Committee (FRAC) based on their modes of action. The two mode-of-action groups most commonly mentioned are Group 3, the demethylation inhibitors (DMI), and Group 11, the quinone outside inhibitors (QoI). Fungicides kill by damaging fungal cell membranes, inactivating critical enzymes or proteins, and/or interfering with key metabolic processes like fungal respiration:

  1. Demethylation inhibitors or DMIs (AKA sterol biosynthesis inhibitors) must be inside plant tissue to be absorbed by the fungus. They are a systemic pesticide. This group inhibits sterol biosynthesis in the fungal cell membrane, DMIs do not prevent spore germination or germ tube growth. Triazoles are in this group. Some examples include Banner MAXX, Eagle, Hoist, Rubigan, and Terraguard.
  2. Quinone outside inhibitors or QoIs act on a broad spectrum of fungi. They inhibit respiration and impede spore germination. They are excellent preventative treatments. They should be applied prior to infection or in the very early stages of disease development. One type of QoI is kresoxim-methyl products (such as Compass O, Cygnus, and Heritage). Another is the strobilurins such as Quadris® (azoxystrobin). Due to the narrow targeting action of strobilurins, fungal resistance is a major concern.

The best method to prevent or reduce a fungal infection is a multi-pronged approach where you rotate through a few various systemic and contact fungicides. The idea is to use methods that possess different modes of action. Your combinations should aim to provide kill on contact, suppress spore production, and limit the development of resistance. We’ll discuss resistance more later, but suffice it to say that you do not want your own personal superfungus.

Note: When applying fungicides, remember to always test for phytotoxicity (toxic to plant growth) on a small area of the plant before use. Some amount of damage may be deemed tolerable when weighed against the alternative of powdery mildew.

Fungicides designed to attack one single protein or enzyme molecule are said to be “single site acting”. Some examples of this are the triazoles (Group 3), which focus on the demethylase enzyme; the strobilurins (Group 11), which target the succinate dehydrogenase enzyme; and the carboxamides (Group 7) that go after the ubiquinol oxidase enzyme.

Fungicides that attack a wide spectrum of pathogens are referred to as “multi-site acting”. Multi-site fungicides are often used with single site products to reduce the risk of developing treatment resistant fungal strains. Examples are copper (sulfates, oxides, hydroxides, and copper linked to organic molecules) and chlorothalonil (Bravo, Echo, and Daconil). Chlorothalonil targets one fungal molecule, but that molecule is widely used. Copper ions damage enzymes critical for fungal cell function.

Another way to describe a fungicide’s mode of action is to say it is used as a protectant, as a curative, or as an eradicant:

  1. Protectants are applied to healthy plants, they employ contact action to prevent fungal spores from germinating or penetrating host tissue. It follows from that that they must be applied before fungal spores infect the plant. Protectants generally are not effective once the fungus grows into plant tissues, so plant tissue that develops after application may not be protected.
  2. Curatives are systemic fungicides that generally act within the plant and are effective against fungi shortly after fungal germination. These products must be applied within a certain time after infection starts.
  3. Eradicants kill fungi on contact. Recent formulations such as triadimefon and myclobutanil not only kill growing mold but also prevent spore production.

Resistance Management

Resistance management is a critical consideration during treatment decision-making. There are two types of resistance: qualitative and quantitative resistance. Qualitative describes an either/or situation: Either the fungus is resistant, or it is not. Either it has, or does not have, the quality known as resistance to the treatment. Quantitative, on the other hand, brings percentage into the picture: Some percentage of the fungi may be resistant to treatment. Some quantity of the fungi is resistant.

For instance, DMI fungicide resistance is almost never 100%. Because DMI resistance is due to more than one mutation, the various organisms will have different levels of resistance. The knee-jerk response of increasing application rate after one pass has failed will usually work in the case of DMI fungicides. Other fungicide groups, like the strobilurins, show qualitative resistance where any application rate becomes ineffective once resistance has developed.

You may have also heard the term “cross-resistance”. Cross resistance exists when a fungus shows resistance to a fungicide because it has resistance to a similar fungicide with the same or similar-enough mode of action.

If you’ve had recent PM outbreaks, it’s not a bad idea to use fungicides protectively before powdery mildew becomes a problem again. Always apply fungicides at their labeled rates and use as many fungicide modes-of-action as possible in your management program.

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Want to get in touch with Quest Hydro? They can be reached via the following methods:

  1. Website:
  2. Email: [email protected]
  3. Phone: 877-420-1330

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About the Author

This educational document was written, compiled, and adapted by Mike Steffes of Quest Dehumidifiers.